Effects of Cannabinoid 1 Receptor Blockade on Macrophages Activated Endocannabinoid System in Coronary Artery Disease and Antiinflammatory
نویسندگان
چکیده
Keishi Miyata, Masafumi Nakayama, Koichi Kaikita, Toru Obata, Motohiro Takeya and Hisao Koichi Sugamura, Seigo Sugiyama, Toshimitsu Nozaki, Yasushi Matsuzawa, Yasuhiro Izumiya, Effects of Cannabinoid 1 Receptor Blockade on Macrophages Activated Endocannabinoid System in Coronary Artery Disease and Antiinflammatory Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2008 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.108.811992 2009;119:28-36; originally published online December 22, 2008; Circulation. http://circ.ahajournals.org/content/119/1/28 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://circ.ahajournals.org/content/suppl/2008/12/29/CIRCULATIONAHA.108.811992.DC1.html Data Supplement (unedited) at:
منابع مشابه
Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages.
BACKGROUND Cannabinoid 1 (CB1) receptor blockade with rimonabant represents a clinical therapeutic strategy for obesity. Recently, the role of the endocannabinoid system has been described in peripheral organs. We sought to determine whether the endocannabinoid system could be involved in human atherosclerosis and whether CB1 receptor blockade could modulate proinflammatory activity in macropha...
متن کاملStudy the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus-Maze
Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat. The EPM is o...
متن کاملRole of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages.
AIMS Evidence from recent studies suggests that the endocannabinoid system participates in the regulation of lipid metabolism and body composition. We hypothesize that the system is activated by oxidized low-density lipoprotein (oxLDL) and regulates cellular cholesterol metabolism in macrophages. METHODS AND RESULTS Primary peritoneal macrophages isolated from Sprague-Dawley rats and RAW264.7...
متن کاملEffect of Cannabinoid Receptor Activation on Spreading Depression
Objective(s) The objective of this study was to evaluate the effect of cannabinoid on cortical spreading depression (CSD) in rat brain. Cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine. CSD is believed to be a putative neuronal mechanism underlying migraine aura and subsequent pain. Materials and Methods T...
متن کاملmembrane-bound receptors and play a role in signal transduction through modulation of adenylate cyclase, mitogen-activated protein kinases (MAPK), and members of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-
Marijuana is the most commonly abused drug in the United States.1 It mainly acts on cannabinoid receptors. There are two types of cannabinoid receptors in humans: cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2). CB1 receptor activation is pro-atherogenic, and CB2 receptor activation is largely anti-atherogenic. Marijuana use is also implicated as a trigger for myocardial...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008